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Moderate deficit works best: 300-500 calorie deficit below maintenance

Elevated NAD+ levels activate sirtuins, particularly SIRT1, which are NAD+-dependent deacetylases that regulate numerous metabolic processes including fat oxidation, glucose metabolism, mitochondrial biogenesis, and cellular stress responses

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The peptide was originally developed by researchers seeking to isolate the lipolytic effects of growth hormone from its other physiological actions
