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Description
For some, its age-related
Homozygous severe mutations cause Beta Thalassemia Major (Cooleys Anemia), leading to severe anemia manifesting in early infancy
Giacco A, Delli Paoli G, Senese R, Cioffi F, Silvestri E, Moreno M, et al
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154156 Notably, studies that met rescue criteria (ferrostatin-1/liproxstatin-1 or iron chelators) and demonstrated pathway involvement (eg, GPX4 or system Xc ) provided stronger translational signals (orthotopic models, dose realism) than descriptive ROS readouts alone
