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These observations proposed that systemic inflammation via induction of neuroinflammation may lead to the degeneration of dopaminergic neurons and the development of PD

Silymarin helps protect existing glutathione from being used up too quickly

This indicates a synergistic interaction , where the combined presence of both elements amplifies the plants antioxidant defense system beyond what is achieved by either element alone

rhamnosus GG can also significantly decrease the mRNA expression of MCP-1 and CD11c, associated with monocyte recruitment and M1 macrophage activation, thereby suppressing the infiltration and activation of M1 cells (Park et al., 2015)

PMCID: PMC10350004 Noronha A, et al