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doi: 10.1089/jamp.2019.1549

Furthermore, a recent study in human subjects showed a significant association between quartiles of serum homocysteine levels and coronary microvascular endothelial dysfunction in patients with early coronary atherosclerosis [88], confirming the detrimental effect of homocysteine on endothelial function

Baillie and Kassahun (1994) state that it seems likely that many xenobiotics with carbamate, formamide, urea, or sulfonylurea functionalities will undergo metabolic transformation to reactive isocyanates and that reversible conjugation to the latter short-lived, potentially toxic intermediates with GSH may play an important role in mediating the disposition and adverse effects of the parent compounds in vivo. 10.17.5.2

Of note, the locus coeruleus is highly enriched in copper (Naeve et al., 1999