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The phase II clinical trial NCT01817751 is evaluating the activity of sildenafil and other drugs (sorafenib and valproic acid) in patients with recurrent high-grade glioma (147, 148), whereas the clinical trial NCT02279992 is evaluating the use of vardenafil to increase systemic concentration of carboplatin in patients with recurrent malignant gliomas or metastatic brain cancer
doi: 10.1126/science.aaw3835
Excessive Fe 2+ is oxidized to Fe 3+ by ferroportin (FPN) to maintain intracellular iron homeostasis (Bogdan et al., 2016)
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Suh K-S, Roh H-J, Choi S-Y, et al
