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Future randomized controlled trials and molecular-level research are needed to clarify the safety, efficacy, and micro-ecological regulatory mechanisms of insoluble fiber in different IBS subtypes

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Science of the Total Environment, 545 , 256265

In HCECs applied with desiccating stress, the CEC ferroptosis was triggered by the aggregation of autophagy impairment-derived sequestosome 1 (SQSTM1), the overexpression of which fostered ferroptotic changes and substantially elevated ACSL4 (124)

Additionally, SASP inhibits the amino acid transporter xCT, which reduced intracellular GSH levels, diminishes cellular antioxidant defense and induces ferroptosis in cancer cells (74)
