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The Phase 2 trial published in the New England Journal of Medicine studied doses ranging from 1mg to 12mg weekly

[PubMed] [Google Scholar] 98.Nanda S, Grover C, Reddy BS

Few adverse effects have been reported from healthy people taking very large doses

Monitoring the effluent at 220 nm, chromatography (flow rate: 18.0 mL/min) was performed starting with a MeOH/H 2 O mixture (85/15, v/v) for 1 min, increasing the MeOH content to 100% within 10 min, holding for 10 min, followed by a decrease of the MeOH content to 85% within 1 min and re-equilibration for 2 min at 85% MeOH

Once the immune system is stimulated, its sends out signals to the rest of the body to recruit more inflammatory cells to specific site