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The kinetic parameters of amyloid formation were determined by fitting the ThT emission curves using where y i + m i t and y f + m f t represent the initial and final baseline values, respectively 70,71,72,73 , t 0 denotes the half-life at which the ThT fluorescence intensity reaches 50% of the maximum amplitude and k represents the elongation rate constant

The core mechanism of ferroptosis involves iron-dependent lipid peroxidation, in which the endoplasmic reticulum-a critical organelle for lipid biosynthesis and protein folding-plays a pivotal role

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analysis of copy number variants (CNVs) and sequencing of coding exons 2 to 8 of SULT1A1 , SULT1A2 and SULT1A3-4 as well as non-coding exons 1A, 1B and 1C of SULT1A3 , is detailed in supplementary methods and Supplementary Tables 2 and 3