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Description
Proteins that catalyze the classical conjugase reaction using GSH are found in several classes
Both fall well below the 10 kDa threshold
Although altered specificity in the GS reaction mechanism offers a direct route to analog synthesis, it is possible that other enzymes catalyze additional reactions that modify glutathione into the specialized peptides, like hydroxymethylglutathione
"Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands"
The sequences of the sgRNAs used in this study are listed in Supplementary Table 1
