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As the biologically active fragment Ac-SDKP, it is primarily studied for its roles in actin upregulation and cellular mobility, angiogenesis and new blood vessel formation, collagen architecture and extracellular matrix remodeling, reduction of fibrotic scarring in soft tissue models, and systemic recovery signaling across multiple tissue types

The popliteal cyst is most dramatically seen on the T-2 or fat suppressed sequences, in which the cyst generally manifests well defined increased signal

This research summary reviews its discovery, chemistry, preclinical biology, limited clinical data, and unanswered mechanistic questions.