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139 The acetate-polymalonate pathway A fourth route to synthesize plant 1,4-NQs, the acetate-polymalonate pathway (also referred to as the polyketide pathway), relies on CoA-linked acetate and malonate substrates, occurs throughout at least half a dozen unrelated families, 7 and is most notably responsible for the production of plumbagin (5-hydroxy-2-methyl-1,4-NQ), droserone (3,5-dihydroxy-2-methyl-1,4-NQ), 5- O -methyldroserone and 7-methyljuglone (Figure 2), as well as bis-1,4-NQs, such as chitranone and diospyrin (Figure 1b)