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Cancer Immunotherapy: Harnessing the Immune System to Battle Cancer

During the pathogenesis of OA, JUN directly binds to the promoter of NCOA4 and initializes its transcription, increasing ferritinophagy degradation, leading to ferroptosis and extracellular matrix degradation in chondrocytes

In particular, lower levels of adiponectin and increased expression of TNF- and its soluble receptor have been recently related to the development of NASH (43)

Int J Epidemiol 2009:39(2):539-562

However, the mechanisms employed by GSK3 to exert these effects remain unclear
