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Unlike Erysipelatoclostridium , Lactobacillus was significantly and dramatically increased in 5A-1MQ-treated mice switched from WD to LD relative to their vehicle-treated counterparts and the LD control group

In proof-of-concept studies, NNMT inhibitors (NNMTis) have demonstrated promise as potential treatments for obesity and obesity-related metabolic comorbidities (e.g., T2D, fatty liver) 8,9,13

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