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High levels of several key pro-inflammatory cytokines, such as IL-1, IL-2, IL-6, TNF-\(\alpha\), IFN-\(\gamma\), IP-10, GM-CSF, MCP-1, and IL-10, some of which also correlate with COVID-19 severity

For some people, this is, again, a place where Tirosint might be of benefit

Isoprostanes are present in relatively large amounts (tenfold greater in blood and urine than the COX-derived prostaglandins)

Vitamin D Insufficiency, Plasma Cytokines, and Severe Asthma Exacerbations in School-Aged Children

Furthermore, a study revealed that liver-specific Zip8 KO mice exhibited significant decreases in systemic Mn levels under both Mn-rich and Mn-depleted conditions, indicating that hepatic ZIP8 mediates Mn reabsorption from bile to help maintain systemic homeostasis (Powers et al., 2023)