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However, DAO levels are affected by factors such as diet [86], alcohol consumption [87], sex [88], menstrual cycle [89] and pregnancy status [90] which challenge its reliability as a biomarker [91]

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[1] [6] Severe deficiencies may include symptoms of reduced heart function, suppression of bone marrow, as well as more various severe neurological symptoms possibly including sensory loss, abnormal balance and reflexes, memory and consciousness impairment, smell and taste problems, depression, irritability, confusion, and psychosis