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doi: 10.1186/s13148-019-0656-7

doi: 10.1242/dev.067587 [DOI] [PubMed] [Google Scholar] 46
In fact, many prominent ASD risk genes encode histone methyltransferases and demethylases, such as euchromatic histone lysine methyltransferase 1 (EHMT1), lysine methyltransferase 2C (KMT2C), and lysine-specific demethylase 1 (LSD1) [91]
Studies have shown that apoptosis-promoting transcription factors such as CHOP, c-JNK, and caspase 12 are activated when cells are exposed to excessive or sustained ERS (Wang et al
Catabolic states Clinical investigators have shown that IGF-I levels are often significantly altered in catabolic states, including the acute postoperative period[367], burn patients[368] and chronic catabolic illnesses, such as cystic fibrosis[369] and HIV with wasting[370]
