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The accumulation of free Fe2+ in these iron reserves leads to an excess of ROS through the Fenton reaction or lipoxygenases (LOXs), initiating lipid peroxidation of polyunsaturated fatty acids (PUFAs) and ultimately inducing ferroptosis [39]

However, CAR T cell therapies for solid tumors remain a challenge due to problems with tumor heterogeneity, cytokine release syndrome (CRS) and CAR T cell exhaustion

The H 2 in the ERW inhibited cancer cell survival and induced apoptosis

OGC, malate/-ketoglutarate exchanger

Hsieh MJ, Lee CH, Chueh HY, Chang GJ, Huang HY, Lin Y, et al
