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Number of reactions per 10,000 doses sold between 2010-2014 (that were reported), please note that some people do not record adverse reactions so numbers could be significantly higher: Dogs Cats Allergic conditions 2663 187 Anaphylaxis 332 29 Dyspnea 155 110 Vomiting 2511 1131 Diarrhoea 791 402 Loss of consciousness 141 8 Pain 240 176 Lethargy 1923 1473 Fever 132 438 Malaise 17 17 Vasculitis 13 1 Cough 445 16 Respiratory disorders 346 85 Injection site reaction 1144 689 Injection site sarcoma 2 148 Death 104 161 Suspected lack of efficacy 228 39 Neurological disorders 459 249 Autoimmune disorders 27 8 It again is highlighted that protective and susceptible gene halotypes have been identified in dogs demonstrating genetic predispositions to hypersensitivities and adverse reactions to vaccinations

Since insulin was first used in 1921, more than 100 peptide-based drugs have been approved by the U.S

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Importantly, erastin-treated lesions exhibit significantly increased iron concentrations, supporting VDAC-mediated iron dysregulation as a key mechanism (Le et al., 2025)