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Furthermore, researchers have reported the presence of mitochondrial abnormalities, indicating a causal relationship between mitochondrial dysfunction and PD

Potential Side Effects While there are no large randomized controlled studies, some common side effects reported include injection-site reactions (pain, erythema, swelling), headache, nausea, diarrhea, and rare hypersensitivity reactions

22 25 Peroxynitrite, derived from the reaction of NO with superoxide anion (see Figure 16-1B), is also regarded as a major cellular nitrating agent

Molecular mechanisms leading to a disturbance of neuroplasticity are not known

However, the widespread adoption of HDTs requires further validation through large-scale clinical trials to establish their efficacy, safety, and cost-effectiveness in diverse populations