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This strategy was aimed to validate the ability of the cellular components of the immune system to reject tumors and is the basis for many gene immunotherapy strategies, including CAR-T cells ( CAR-T therapy involves genetically modifying T cells to express a chimeric antigen receptor (CAR), enabling them to recognize and eliminate cells expressing a particular antigen in a very potent response

Knockout or overexpression of PRMT1 in TECs can alleviate or aggravate CaOx-induced renal injury by regulating fatty acid metabolism TEC-specific PRMT1 overexpression mice were generated by injecting rAAV9 carrying either a TEC-specific Ksp promoter-driven PRMT1 construct (rAAV9-Ksp-PRMT1) or an empty vector (rAAV9-Ksp-null) into the bilateral kidneys using a microliter syringe to further evaluate the role of PRMT1
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