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2B) and in vivo (Fig

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Prostaglandin E2 (PGE2) is one of the main members of the prostaglandin family, and studies have shown that low concentrations of PGE2 promote osteoblast differentiation and proliferation, whereas high concentrations of PGE2 stimulate osteoclasts to promote bone resorption, which is involved in maintaining the dynamic balance of bone (Fig

The condition was assessed solely through clinical observation, without distinguishing between different subtypes based on pigment depth or morphological patterns

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