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Takeaway: Do not expect cosmetic skin improvements

1.5 mg/kg, IP), elicited pronounced withdrawal phenomena in rats which received a subcutaneous depot of morphine (150 mg/kg) for 36 h and were receiving a continuous infusion of saline (20 L/h, IV) via osmotic minipumps for the same 36 h period

doi: 10.1016/j.ebiom.2021.103512
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However, with the continuous use of targeted drugs, some patients exhibit resistance

ISBN 978-0-262-10107-3
