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Current research has found that the peptide can successfully induce tumor cell necrosis in both solid and non-solid tissues dependent on the expression of HDM-2 and selective transmembrane pore formation

[DOI] [PMC free article] [PubMed] [Google Scholar] Nuber S, Zabel U, Lorenz K, Nuber A, Milligan G, Tobin AB, Lohse MJ, Hoffmann C

or 4) use of a peptide bond isostere in place of the 1-2 peptide bond

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans[S

These synthetic versions last days to weeks, maintaining sustained receptor activation throughout the dosing period