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Its antioxidant power promotes healthy aging, protects the skin, reduces hyperpigmentation, and improves general health

2020 doi: 10.1016/j.ejps.2019.105158

48 Moreover, the Midostaurin, inhibitor of Pan-PKC, could directly have effect not only on the leukemic cells but also on the AML neighboring stromal cells in the bone marrow (BM) microenvironment

This mechanistic rationale is why many GH-axis research protocols pair GHRPs with GHRH-family compounds

Conclusion: Altogether, our results show that the cellular antioxidant defense systems contribute to leukemia resistance to MTX, and targeting these pathways, especially the thioredoxin antioxidant system, may be a promising strategy for resensitizing ALL to MTX
