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Within HSCs, curcumin enhances PPAR functionality while mitigating oxidative stress through Ob-R dephosphorylation, subsequently suppressing Ob-R transcription and blocking leptin-mediated signaling, thereby abolishing leptins pro-activation effects on HSCs (Tang et al., 2009)

Moreover, the data based on epidemiological analysis, clearly suggested that liver cirrhosis had inverse relationship with coffee consumption

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Researchers found that a protective enzyme called GPX4 which prevents a specific type of cell death called ferroptosis is significantly reduced in the granulosa cells of women with declining ovarian reserve

176 (3) the AOL domain, which is an amine oxidase-like domain locating at the C-terminal of LSD1 and is divided into two regions by the Tower domain, one is used for substrate binding and recognition, and the other is defined as the binding site of non-covalent FAD (Fig