melanotic macule increased melanocytes Case of in a 46/F Let's review ORAL MELANOTIC MACULE/ FOCAL MELANOSIS . The oral melanotic macule is a flat, brown, mucosal discoloration produced by a focal increase in melanin Melanotic macules of the tongue

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Radiculopathy, including symptoms such as pain and numbness, is present in 92% of patients with paraspinal tumors of this nature, as also seen in this case

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Only free thyroid hormone is metabolically active Thyroid hormone affects metabolism in all tissues in the body via a variety of mechanisms Thyroid hormone increases the expression and sensitivity of beta-adrenergic receptors resulting in an increased response to endogenous catecholamines (this accounts for many of the symptoms seen in thyroid storm) Wolff-Chaikoff Effect: Excess iodide transiently inhibits thyroglobulin iodination and release of thyroid hormone Jod-Basedown Effect: Iodide load induces hyperthyroidism in susceptible subgroups (i.e