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This hypothesis is supported by the appearance of lesions of HFSR specifically in areas chronically exposed to friction and with preexisting hyperkeratosis.20 Recently, the existence of a genetic predisposition to develop sorafenib-induced HFSR has been described in patients with hepatocellular carcinoma.21 Dranitsaris et al.22 developed and validated a predictive model for the onset of HFSR in patients receiving treatment with sorafenib.23,24 The management of HFSR is summarized in Table 3

Meyer TW, Hostetter TH (2012) Uremic solutes from colon microbes

[DOI] [PubMed] [Google Scholar] 204.Mitochondrial Medicine Society's Committee on Diagnosis