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The resulting compound has reported serum half-life and blood-brain-barrier permeability sufficient for oral and intragastric administration in rodent studies, which is unusual for a peptide derivative of this size

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A lthough the model study supports the feasibility of a peroxycyclization dioxetane-fragmentation mechanism for the formation of HNE as well as HOOA and HODA derivatives, it remains to be demonstrated that lipid peroxy radicals actually undergo such a cyclization-fragmentation