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Mirabello L, Troisi RJ, Savage SA

But it does so in an episodic manner

Biomed Pharmacother 171:116112 Liu X et al (2022) SLC7A11/GPX4 Inactivation-Mediated Ferroptosis Contributes to the Pathogenesis of Triptolide-Induced Cardiotoxicity

These findings suggest that, when evaluating the effects of amino acid-related metabolic axes, such as Gln-KG, on macrophage polarization, the key is not to simply classify them as pro-inflammatory or anti-inflammatory, but rather to focus on their integrated effects on anaplerotic flux, the spectrum of signaling metabolites, and the supply of epigenetic substrates, thereby reshaping inflammatory thresholds and reparative capacity across different timescales ( Nutrient-sensing pathways provide important clues for explaining the discrepant findings among different studies