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The results were significant: At 48 weeks, participants receiving the 12 mg dose achieved a mean weight reduction of 24.2% (approximately 58 pounds or 26.2 kg) 100% of participants on the 8 mg or 12 mg doses lost at least 5% of their body weight More than 90% of participants on the 12 mg dose lost at least 10% of their body weight Nearly half of participants on the highest dose lost 25% or more of their body weight The study also showed improvements in cardiometabolic markers including blood pressure, triglycerides, LDL cholesterol, and fasting glucose

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The route of administration matters

We performed confocal microscopy and analyzed PLIN2-stained LDs, confirming that HSL inhibition in M2 macrophages (M2 + HSLi) significantly increased the total LD volume per cell compared with untreated M2 cells (Fig