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Preclinical studies demonstrate that LAT1 inhibition reduces tumor growth and enhances responses to other therapies

Welsh et al., 2009), Drosophila melanogaster (Tour et al., 2023), zebrafish (Cafora et al., 2019

KD appears to provide a potential therapeutic benefit for patients with neurodegenerative diseases, including PD, by controlling and moderating the balance between excitatory and inhibitory neurotransmitters, as well as modulating inflammation or altering the composition of the gut microbiome (121, 122)

Conclusions The publication of the 2024 NICE guidelines on B 12 deficiency represents progress but falls short by proposing to rename pernicious anaemia with autoimmune gastritis. This change does not adequately address the distinct nature of PA as an advanced stage of AIG, characterised by IF deficiency requiring lifelong B 12 treatment