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While carnitine supplementation could have benefits, some recent studies suggest that chronic oral L-carnitine administration may be associated with an increased risk for atherosclerosis via increased trimethylamine (TMA) and/or trimethylamine N-Oxide (TMAO) levels (54, 55)

L-carnitine-supplementation in advanced pancreatic cancer (CARPAN)a randomized multicentre trial

Metabolism of very long-chain Fatty acids: genes and pathophysiology

Mathur R, Barnett BE, Hermanson D, He J, Zhang Z, Rengarajan S, Codde R, Wang X, Tan Y, Martin C, Smith J, Lee HC, Manasanch EE, Thomas SK, Patel KK, Weber DM, Davis RE, Orlowski RZ , Ostertag EM, Shedlock D, Yang J, and Neelapu SS

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