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Using MSC exosomes or their modified products, or bioactive tissue engineering scaffolds, in combination with GPX4-enhancing small molecules, can promote tissue repair and regeneration while effectively reducing ferroptosis levels in implanted cells or host chondrocytes, thereby improving the survival rate and tissue integration of implants (Singhmar et al., 2025
Together, they neutralize ROS and their products of action, alleviating oxidative stress ( Besides, SFN can potentially alleviate/break the vicious cycle of oxidative stress and gut dysbiosis shown in Figure 4
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Research suggests that glutathione may help to ward off both ocular diseases as well as the normal effects of aging on the eye
