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Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-linked -N-acetylglucosamine in 3T3-L1 adipocytes

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However, the convenience of a single morning dose means most researchers prefer once-daily administration, and the clinical data supporting split dosing specifically for AOD 9604 is limited

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The net result is a shift toward fat oxidation rather than fat storage