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Long-term safety endpoints had the primarily purpose of excluding the presence of infections due the possible non-sterility of the cell product (a risk minimized by the extensive in vitro examinations), tumor formation (risk minimized by the in vivo evidence obtained by infusion of supra maximal doses of cells in immunosuppressed mice) as well as changes in neurological status that would not be expected based on the disease course

C., Liu, Z., Dillin, A

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Local blood flow and glucose consumption in the rat brain during sustained bicuculline-induced seizures

Hubbard et al