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10.1007/s00726-011-0867-5 22 CuiC.YangF.LiQ
Hasanuzzaman et al., 2017)

Problems with chewing and swallowing food

Doctors at the University of Minnesota also showed that coffee administered rectally can stimulate an enzyme system in the liver called glutathione S-transferase by up to 600%-700% above normal activity levels
