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The structure clearly shows how OCTN2 coordinates both the negative and positively charged moieties of carnitine (Fig

The DNA was extracted and purified from the sample using the DNeasy PowerSoil Pro Kit (Qiagen Italia, Milan, Italy)

In a study of 22 children with UCDs who survived a hyperammonaemic coma, the duration of coma was inversely correlated with the childrens IQ at 12 months after recovery from the hyperammonaemic coma 27,28

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Within this framework, mTOR overactivation appears to function maladaptively in APOE4 mice, contributing to impaired insulin signalling and vascular function
