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GLUTATHIONE IN ENDOPLASMIC RETICULUM In ER, glutathione exists mainly as oxidized glutathione (GSSG)

[DOI] [Google Scholar] 253.Panossian A., Wikman G

This dual mechanism is what separates it from single-agonist medications like semaglutide and explains why clinical trial results showed superior weight loss outcomes

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The idea is that injecting glutathione gives higher, more immediate systemic levels than oral or topical forms, which theoretically could affect skin pigmentation more strongly