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At present, the only effective drug recombinant tissue plasminogen activator is limited by its indications, and its clinical application rate is not high

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However, their toxicological profiles demand careful evaluation to ensure safety in medicinal and commercial applications

12.6 Pathways of biliverdin production from heme by chain-opening and bilirubin production by reduction of biliverdin (Reproduced with permission from Odell [15]) After its formation in reticuloendothelial cells, bilirubin is released into the bloodstream, where it is transported bound to albumin via one primary and two secondary binding sites

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