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Monaco G, Konopleva M, Munsell M, Leysath C, Wang RY, Jackson CE, Korbling M, Estey E, Belmont J, Andreeff M

Cellular & Molecular Biology Letters 27, 4

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Discussion There were two key findings in this study of older HIV-infected patients: 1) deficient intracellular GSH synthesis and decreased GSH regeneration contribute GSH deficiency and can be corrected with short-term cysteine plus glycine supplementation and 2) correcting GSH deficiency was associated with marked improvements in mitochondrial fuel oxidation in the fasted and fed states, insulin sensitivity, muscle strength, and body composition