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doi: 10.1124/dmd.114.057232

Considering that eukaryotic cells do not have the intrinsic capacity to produce folate, because of the lack of enzymes necessary for its de novo synthesis [34], humans must obtain folate from their diet or through supplementation to prevent health problems [35] (for details, see Section 5, Folate Metabolism and Cancer, and Section 6, Folate Metabolism and Neurodegeneration)

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Serum ammonia levels may also benefit from standardized guidelines on collection, laboratory analysis, and interpretation

While research on G6PDH and PPP has historically focused on mammalian models, particularly human disorders, recent studies have shed light on the regulation of this enzyme in arthropods, where new functions were discovered