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These results highlight tissue-specific mitochondrial reprogramming to support liver energetic demands and antioxidant synthesis, rather than global mitochondrial dysfunction, as a metabolic consequence of sepsis

Cysteine is a rate-limiting precursor substrate for GSH synthesis, and its level is regulated by SLC7A11 encoding the cystine/glutamate transporter XCT, which is primarily responsible for the export of glutamine in exchange for extracellular cystine [9]

Proton Coupled Folate Transporter (PCFT): The proton coupled folate transporter (PCFT) is a recently identified bidirectional transmembrane folate carrier and is encoded by the SLC46A1 gene in humans

Vitamin B12, folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation