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Figure 10 shows that GSH deficiency ( GCLC -KD) caused a simultaneous increase in TNF- and decrease in VDR/PGC-1/GLUT-4 mRNA expression in GCLC -KD C2C12 myotubes (Fig

Mitochondrial dysfunction, including systemic deficiency of the electron transport chain complex I, is a well-established player in the pathogenesis of both sporadic and familial PD [96,97,98]

Barba, C

Glucose deprivation reduces the PPP-mediated NADPH generation, making it impossible to reduce insoluble cystine imported via xCT to a more soluble cysteine, thereby inducing disulfide stress (i.e., cystine-dependent toxicity) and leading to rapid cell death [48] [Figure 3B]

Wild specimens were found, but the bud regeneration procedure was unsuccessful