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C.ChenH.FanJ.PapadopoulosV.MillerP.ZirkinB

The compounds quinolinium scaffold confers membrane permeability that enables intracellular enzyme inhibition, distinguishing it from earlier polar NNMT inhibitor scaffolds that did not effectively enter intact cells

10.1186/1741-7015-7-62 BMC Med

1.2 The Use of Adverse Outcome Pathways in Genotoxicity Assessment Genotoxicity assessment determines the ability of chemicals to cause genetic damage, such as chromosomal aberrations and mutations, which can lead to cancer ( To facilitate the development of mechanism-based testing and its use in genotoxicity assessment, AOPs corresponding with mechanisms of genotoxicity are under development ( in various phases of development
