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With the matched group on semaglutide, 28 reported gastroparesis.[ref][ref] Diabetic retinopathy: Two clinical trials in people with diabetes linked GLP-1 RA drugs to an increased risk of diabetic retinopathy, while other studies show that the drugs were not associated with the eye disease

Studies in rats [61] also suggested that both VPA and its unsaturated metabolites inhibit -oxidation through different mechanisms, such as sequestration of CoA-SH and direct inhibition of specific enzymes in the -oxidation sequence by CoA esters, particularly 4-en-VPA-CoA

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doi: 10.1089/jmf.2016.0070

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