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Some common side effects may include: Irritation at the injection site Fatigue Nausea Storage Store at controlled room temperature

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Niraparib showed promising activity in preclinical models and phase I clinical trials, achieving its pharmacodynamic target for PARP inhibition in epithelial ovarian cancer, particularly in patients who have responded to platinum-based chemotherapy 167 (Fig

It is possible the human trials never delivered enough intact peptide to the relevant tissue to reproduce the rodent effect, though this remains a hypothesis rather than a demonstrated cause of failure