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Kalmodia S, Vandhana S, Tejaswini Rama BR, Jayashree B, Sreenivasan Seethalakshmi T, Umashankar V, et al

In this study, we utilized the small molecule PFK15, a competitive inhibitor of the rate limiting glycolysis enzyme 6-phosphofructo-2-kinase/fructose-2,6- biphosphatase 3 (PFKFB3)

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Moreover, the XiaoPi formula can counteract the secretion of CXCL1 and -catenin, further diminishing the self-renewal and chemotherapy resistance of the cancer cells (Zheng et al., 2020)

Consistent with this, the observation of reduced viability of H9c2 cardiomyoblasts and HUVEC endothelial cells to values below 80% when incubated with GSNO concentrations above 75 m and 156 m, respectively, indicates that the cytotoxic effect of high GSNO concentrations, such as 500 m, may prevail over the beneficial effect of cardioprotection in I/R