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Description
Importantly, these effects occur without activation of growth hormone receptor pathways or alteration of IGF-1 signaling, allowing AOD 9604 to be used as a tool for isolating metabolic signaling mechanisms
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This hypothesis was validated in a preclinical melanoma model, where blocking CD38 expression in T lymphocytes boosted NAD + levels, improving the effectiveness of adoptively transferred T cells (47)

The reasons: The mechanism is complementary to GLP-1 agonists
