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[DOI] [PubMed] [Google Scholar] 34.Bloch K
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Moreover, the greater stability of the Cagri-induced bypass conformation relative to the rAmy-induced bypass conformation, when engaged with the CTR, is likely a major contributor to the increased conformational stability of the Cagri-AMY 2 R-Gs complex relative to the rAmy-AMY 2 R-Gs complex
The route isnt a minor detail
However, this feature is also exploited by cancer cells to acquire drug resistance and improve their survival
