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Other notable observations included two separate occurrences of spontaneous compartment syndrome, suspicion of nonaccidental injury due to significant bruising, and significant clinical variability regarding the debilitating effect of joint dislocations
In response to these issues, EVs are increasingly being functionalized using engineering strategies, including membrane modification and cargo loading
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A cell surface receptor called programmed death-1 (PD-1) acts as a T cell checkpoint and is critical in controlling T cell exhaustion
[PubMed 5655478] 14
